Commentary on use of PPIs and aspirin to prevent EAC

A thoughtful commentary on the strengths and weakness of the recent clinical trial of PPI and aspirin.

Nat Rev Clin Oncol. 2018 Dec;15(12):728-730. doi: 10.1038/s41571-018-0096-x.

Chemoprevention of Barrett’s oesophagus: a step closer with PPIs and aspirin.

Husain NS1,2, El-Serag HB3,4.

Chemoprevention for patients with Barrett’s oesophagus remains a
controversial topic. Results of the first randomized trial of chemoprevention
using a proton pump inhibitor with or without aspirin were recently reported.
We highlight strengths and weaknesses in the design of the trial and discuss
the clinical implications of the findings.

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This website contains a curated and opinionated look at recent literature regarding the epidemiology and prevention of esophageal cancer, with an emphasis on esophageal adenocarcinoma. It is developed by Thomas L Vaughan MD, MPH, who can be reached with questions or suggestions through email or his research website.
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