Trends in Esophageal Cancer Incidence in England

Investigators from Queen Mary University of London examine past trends in esophageal cancer incidence and project a leveling off in rates of esophageal adenocarcinoma over the next two decades in England.

Br J Cancer. 2018 May;118(10):1391-1398. doi: 10.1038/s41416-018-0047-4. Epub  2018 Mar 22.

Trends and projections in adenocarcinoma and squamous cell carcinoma of the oesophagus in England from 1971 to 2037.

Offman J1, Pesola F2, Sasieni P2,3.



The aim of this study was to assess the incidence and trends of oesophageal adenocarcinomas (OACs) and squamous cell carcinomas (OSCCs) in England from 1971 to 2037.


Data  on 220,026 oesophageal cancers diagnosed in England between 1971 and  2013 were extracted. Multiple imputation was used to predict morphology  data were missing. Incidence rates were modelled and extrapolated to  2037 using age-period-cohort models.


The OAC  age-standardised incidence rate (ASRs) increase was greatest from 1972  to 1992 (from 4.8 to 12.3 for men and 1.1 to 3 per 100,000 for women)  and slowed from 1992 to 2012 (with an increase to 17 for men and 3.8 per  100,000 for women). OSCCs rates decreased from 7.5 to 4.9 from 1972 to  2012 for men. For women, ASRs increased from 5.5 to 5.9 between 1972 and  1992 and then decreased to 4.7 per 100,000 until 2012. Rates until 2032  are predicted to stay stable for OACs and further decrease for OSCCs.


Imputing missing morphology allowed accurate and up-to-date estimates of trends and projections. We observed a slowing down of the increase in OAC ASRs and an overall decrease in OSCC ASRs.

This website contains a curated and opinionated look at recent literature regarding the epidemiology and prevention of esophageal cancer, with an emphasis on esophageal adenocarcinoma. It is developed by Thomas L Vaughan MD, MPH, who can be reached with questions or suggestions through email or his research website.
©2021 Thomas L Vaughan
This website should not be considered, or used as a substitute for, medical advice, diagnosis or treatment. This site does not constitute the practice of any medical or other professional health care advice, diagnosis or treatment. The information on this website represent the views solely of Dr. Vaughan.
Cookies are used to quantify website use for resource planning.  Complete IP addresses are not collected (i.e., will be  recorded as 203.0.113.??) Feel free to opt out of cookies using add-ins of your choice without affecting website function.  No user information is collected by the risk calculator (IC-RISC).