Screening and early diagnosis of upper GI neoplastic lesions: dedicated journal issue

Tom Vaughan

08 Jul 2025

The journal "Best Practice & Research Clinical Gastroenterology" has dedicated an entire issue toward research on the secondary prevention of esophageal and other upper GI cancers. These review articles include such topics as artificial intelligence, risk-based screening and cost effectiveness. Rather than summarizing these 12 informative articles, I have posted the following link to the journal issue with an option to download the open source articles, which were edited by Drs. J. Honing and M.D.Ribeiro.

Improvements in post-surgical mortality for esophageal cancer

Although esophageal cancer remains one of the most deadly cancers, this Swedish population-based study from the Karolinska Institutet documents steady improvement in five-year survival rates over the past two decades. Among 2,291 patients undergoing esophageal cancer surgery, survival increased by about 3% per year despite patients being older and

Real-world experience with capsule sponge test

This large prospective observational study evaluated the potential usefulness of the Capsule Sponge (CS) test – a non-invasive method of collecting cellular samples from the esophageal lining – in a "real-world" setting at multiple NHS hospitals in the UK. Among the 2,170 patients who had a CS test, there

Circulating tumor DNA and recurrence of esophagogastric cancer

Persons with esophagogastric adenocarcinoma who undergo neoadjuvant therapy and curative-intent surgery are unfortunately still at risk for recurrence even with pathological complete (or near-complete) treatment response. If those likely to experience recurrence could be identified early they might benefit from additional treatment such as immunotherapy. This preliminary study investigates the

Cost-effectiveness analysis of Barrett's screening

From South Australia's Flinders University, Dr. Aoki and colleagues report on a cost-effectiveness analysis of various screening strategies for identifying Barrett's esophagus (BE) in the community, The study examined four primary screening tools: non-weighted clinical risk stratification, weighted risk stratification, the Cytosponge-TFF3 device, and traditional endoscopy

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Improvements in post-surgical mortality for esophageal cancer

Real-world experience with capsule sponge test

Circulating tumor DNA and recurrence of esophagogastric cancer

Cost-effectiveness analysis of Barrett's screening