Welcome to ESOCAN

An educational resource dedicated to the
prevention and control of esophageal cancer.

Each year over 600,000 people in the world are diagnosed with esophageal cancer. Unfortunately most do not survive more than a year, making it the sixth most common cause of cancer-related death. Much is known about the risk and protective factors for this cancer, providing opportunities for prevention through

avoiding causative exposures,
engaging in healthy activities,
chemoprevention, and
screening for precancerous conditions (in some cases)

Cancer-related mortality worldwide - 2020

Of the almost 10 million cancer-related deaths that occurred in the world during 2020,
5.5% were attributable to esophageal cancer. (Cancer Today)

Purpose

The purpose of this website is to promote awareness of esophageal cancer, summarize its epidemiology (see background and risk and preventive factors) and demonstrate how this information can be used for personalized cancer prevention. See "Learn More" below and menu tab.

New research findings relevant to esophageal cancer causes and prevention will be highlighted from time to time in the blog. If you would like updates delivered to your inbox (1 - 2 per month), sign up for the newsletter.
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Most esophageal cancers worldwide are classified as squamous cell carcinomas. In the early 1970s, however, a previously unusual histologic type - adenocarcinoma - began a rapid rise in incidence that continued for over four decades to become the dominant type of esophageal cancer in the West. The BEACON consortium tab summarizes findings from this epidemiologic research consortium which was founded in 2005 to study underlying reasons for the increase and identify potential preventive measures. Additional information resources related to esophageal cancer prevention, treatment and patient support can be found in a menu tab as well.
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Learn more

Background

describes the basic epidemiology of esophageal cancer

Risk Factors

summarizes what is known about possible causes of esophageal cancer and opportunities for prevention

What's Your Risk?

introduces the IC-RISC™risk calculator which estimates an individual’s risk of developing esophageal adenenocarcinoma

Fred Hutch Cancer Center Sign up for newsletter

Recent News:

Review of epidemiology of esophageal cancer and Barrett's

This Review by Dr. Thrift at Baylor updates the trends in the incidence of esophageal cancer (both histologic types) and summarizes current knowledge of its risk factors.

Importance of family history in Barrett's and esophageal adenocarcinoma

Family history of Barrett's and/or EAC was determined in 480 BE patients and 420 controls and validated using the Dutch nationwide histopathology database. A positive family history was found in 6.5% of BE patients, which is consistent with other studies, yielding a five-fold increased risk. The authors emphasize the importance of a detailed family history in patients with BE or EAC to identify individuals at increased risk who may benefit from early detection strategies to prevent EAC-related mortality

About
This website contains a curated and opinionated look at recent literature regarding the epidemiology and prevention of esophageal cancer, with an emphasis on esophageal adenocarcinoma. It is developed by Thomas L Vaughan MD, MPH ©2021

Disclaimer
This website should not be considered, or used as a substitute for, medical advice, diagnosis or treatment. This site does not constitute the practice of any medical or other professional health care advice, diagnosis or treatment. The information on this website represent the views solely of Dr. Vaughan.

Privacy
Cookies are used solely to quantify website use for resource planning. Complete IP addresses are not collected (i.e., 203.0.113.123 will be recorded as 203.0.113.??) Feel free to opt out of cookies using add-ins of your choice without affecting website function. No user information is collected by the risk calculator (IC-RISC).