This prospective cohort study conducted in China aimed to assess the association between long-term exposure to fine particulate matter (PM2.5) and risk of esophageal cancer. The study included over 510,000 participants without esophageal cancer at the beginning of the study and used a high-resolution satellite-based model to estimate
While the ESOCAN website and blog focus on the epidemiology and prevention of esophageal cancer, this review gives insight into recent and developing approaches to the management of esophageal squamous cell and adenocarcinoma. Key points that the authors highlight include: • With advances in molecular profiling technologies, the diferential mechanistic underpinnings
In this unusual and very in-depth review, Dr. Sijben and colleagues perform a qualitative analysis of professional’s views on the justification for systematic screening for esophageal adenocarcinoma (EAC), a topic of much discussion. The findings suggest that professionals in the field are increasingly supportive of targeted screening (as opposed
The following summary made use of an accompanying comment by Drs. Dawsey and Duit: A substantial advance for screening of oesophageal cancer - PubMedA substantial advance for screening of oesophageal cancerPubMedSanford M Dawsey This report discusses the high prevalence of esophageal squamous cell cancer, particularly in low-income and middle-income countries,
This study aimed to investigate whether bariatric surgery is associated with an increased risk of developing esophagogastric carcinoma, using a retrospective design and data from a very large national administrative database of hospital discharges in France. The analysis revealed that bariatric surgery was not associated with an additional risk of
Radio frequency ablation (RFA) has become a standard of care for persons with advanced dysplasia in Barrett's, but little has been published regarding the occurrence and predictors of post-procedure symptoms. This study aimed to describe the course of post-RFA symptoms and identify possible associated risk factors in patients
The article discusses the findings of a community-based, multicenter, prospective cohort study on endoscopic surveillance for premalignant esophageal lesions in rural China. The study aimed to assess the incidence and risk factors for advanced neoplasia in patients with mild-moderate dysplasia. The results showed that most patients with mild-moderate dysplasia stabilized
While not exactly a streetfight, Drs. Spechler and El-Serag briefly discuss in this "point/counterpoint" possible reasons that current screening approaches for esophageal adenocarcinoma and Barrett's esophagus have had only modest success in affecting incidence and mortality for this cancer. I note that neither author mentions
This review nicely updates the status of screening programs for Barrett's esophagus and esophageal adenocarcinoma, with and emphasis on established and newer non-invasive methods. The Horizon of Screening for Barrett's Esophagus and Esophageal Cancer Techniques and Innovations in Gastrointestinal Endoscopy, 2023 https://doi.org/10.1016/
There are a few recent reports that the incidence of EA has increased in young adults, and that they are being diagnosed at a later stage. In an analysis of nine SEER population-based cancer registries from 1975-2015, Codipilly, et al. reported an approximate tripling of incidence in persons less than
Evidence continues to mount from observational epidemiologic studies and animal experiments supporting the notion that statins may be effective chemopreventive agents for esophageal adenocarcinoma, and possibly useful in esophageal cancer treatment as well. In this large (over 1M persons) records-based cohort study in Korea, investigators observed a 45% reduction in
Last week I posted figures summarizing changes in age-adjusted incidence rates of esophageal adenocarcinoma (EA) over the past 20 years according to demographic characteristics, using the latest data from 14 population-based registries in NCI's SEER program (https://www.esocan.org/ea-rates-increasing/). This post focuses on changes in incidence