Review of chemoprevention status for esophageal adenocarcinoma
Dr. Bill Grady and colleagues review the status of chemopreventatives for progression of Barrett's to esophageal adenocarcinoma
Tom Vaughan
Mathematical modeling suggests older ages for beginning screening
Kit Curtius and colleagues demonstrate how mathematical modeling of cancer evolution can be used to optimize age at initial screening for Barrett's and esophageal adenocarcinoma, suggesting an older start.
Early age of reflux symptoms predictive of Barrett's
This study from Kaiser Permanente Northern California oberved that early onset of reflux symptoms approximately doubles risk of Barrett's esophagus, and that both severity and frequency of reflux symptoms are important in predicting risk.
Childhood obesity and subsequent esophageal cancer risk
Dr. Petrick and colleagues reported on childhood obesity and subsequent risk of esophageal and gastric cancer in over 60,000 young Danish men. This is one of the first studies that indicate that reduction in obesity between childhood and adulthood may reduce subsequent risk.
Sleep apnea and BE
This provocative study, while based on a chart review, suggests that persons with obstructive sleep apnea have a three-fold increased risk of BE even after controlling for obesity and reflux symptoms.
Risk calculator for esophageal adenocarcinoma
This paper describes the development of the IC-RISC™ calculator and provides examples of its application in the general population and among persons with Barrett’s esophagus. (See “What’s Your Risk” menu above for the actual calculator.)
Welcome to ESOCAN
An educational resource dedicated to the prevention and control of esophageal cancer. Each year over 600,000 people in the world are diagnosed with esophageal cancer. Unfortunately most do not survive more than a year, making it the sixth most common cause of cancer-related death. Much is known about the
Esophageal cancer background
The esophagus (blue in figure) is a muscular tube that carries food from the back of the mouth (pharynx – green) to the stomach (red) (figure 1). Cancers that occur in this organ are often difficult to treat, in part because “alarm symptoms” such as difficulty swallowing (dysphagia) or bleeding often
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Risk and Protective Factors
Esophageal Adenocarcinoma Epidemiologic and clinical research has revealed many risk factors which, taken together, can help estimate a person’s probability of developing esophageal adenocarcinoma (EAC). These include: * demographic factors, * host and lifestyle factors, * medications, * family history, and * genetic markers. In the general population, symptomatic gastroesophageal reflux (sGERD), obesity, cigarette