The following summary made use of an accompanying comment by Drs. Dawsey and Duit: A substantial advance for screening of oesophageal cancer - PubMedA substantial advance for screening of oesophageal cancerPubMedSanford M Dawsey This report discusses the high prevalence of esophageal squamous cell cancer, particularly in low-income and middle-income countries,
This study aimed to investigate whether bariatric surgery is associated with an increased risk of developing esophagogastric carcinoma, using a retrospective design and data from a very large national administrative database of hospital discharges in France. The analysis revealed that bariatric surgery was not associated with an additional risk of
Radio frequency ablation (RFA) has become a standard of care for persons with advanced dysplasia in Barrett's, but little has been published regarding the occurrence and predictors of post-procedure symptoms. This study aimed to describe the course of post-RFA symptoms and identify possible associated risk factors in patients
The article discusses the findings of a community-based, multicenter, prospective cohort study on endoscopic surveillance for premalignant esophageal lesions in rural China. The study aimed to assess the incidence and risk factors for advanced neoplasia in patients with mild-moderate dysplasia. The results showed that most patients with mild-moderate dysplasia stabilized
While not exactly a streetfight, Drs. Spechler and El-Serag briefly discuss in this "point/counterpoint" possible reasons that current screening approaches for esophageal adenocarcinoma and Barrett's esophagus have had only modest success in affecting incidence and mortality for this cancer. I note that neither author mentions
This review nicely updates the status of screening programs for Barrett's esophagus and esophageal adenocarcinoma, with and emphasis on established and newer non-invasive methods. The Horizon of Screening for Barrett's Esophagus and Esophageal Cancer Techniques and Innovations in Gastrointestinal Endoscopy, 2023 https://doi.org/10.1016/
There are a few recent reports that the incidence of EA has increased in young adults, and that they are being diagnosed at a later stage. In an analysis of nine SEER population-based cancer registries from 1975-2015, Codipilly, et al. reported an approximate tripling of incidence in persons less than
Evidence continues to mount from observational epidemiologic studies and animal experiments supporting the notion that statins may be effective chemopreventive agents for esophageal adenocarcinoma, and possibly useful in esophageal cancer treatment as well. In this large (over 1M persons) records-based cohort study in Korea, investigators observed a 45% reduction in
Last week I posted figures summarizing changes in age-adjusted incidence rates of esophageal adenocarcinoma (EA) over the past 20 years according to demographic characteristics, using the latest data from 14 population-based registries in NCI's SEER program (https://www.esocan.org/ea-rates-increasing/). This post focuses on changes in incidence
The habitual intake of very hot beverages has long been implicated in increasing risk of ESCC in higher-incidence areas in China, Iran and other countries, but is less well studied in high-incidence countries of East Africa. In this carefully-conducted case-control study in Malawi and Tanzania, investigators observed consistently elevated risk
A number of observers have noted that the incidence of esophageal adenocarcinoma (EA) appeared to plateau beginning in the early years of the millennium (e.g., Pohl, 2010; Cook, 2021.) To see whether this leveling off has continued, I examined the incidence of EA over the last 20 years (2000-2019)
IARC's GLOBOCAN database was used to estimate the worldwide esophageal cancer burden in 2020, and to project to 2040 under various assumptions. In 2020 over 600,000 cases were estimated to have occurred, rising to almost 1 million in 2040 unless more effective prevention programs are implemented. Gastroenterology.